Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1379 | Thyroid (non-cancer) | ECE2017

Effects of combination of metformin and pioglitazone on AMPK/mTOR signal pathway, p53 and apoptosis in human anaplastic thyroid cancer cells

Kutbay Nilufer Ozdemir , Erdogan Mehmet , Yurekli Banu Sarer , Kurt Cansu Caliskan , Gunduz Cumhur , Avci Cigir Biray

Thyroid cancer is the most common malignant tumor of the human endocrine system. Recently, its incidence has increased significantly. Anaplastic cancer constitutes 2–4% of thyroid cancers and remains aggressive. The life expectancy is 2–6 months. It is often beyond the surgical margin. External radiation therapy or chemotherapy are the treatment options. Therefore, new therapeutic approaches are needed. Peroxisome proliferator-activated receptor (PPAR) gamma is a DNA...